Toxic apoptosis

Toxic apoptosis

In This Issue In This Issue Toxic apoptosis antel et al. report that ␣-toxin from Staphylococcus aureus can induce apoptosis in immune cells (page 637). This may help the bacterium to immunosuppress the victim and continue proliferating. S. aureus was known to induce apoptosis, but the underlying mechanism was unknown. Bantel et al. find that the inducer is soluble. B Apoptosis can be triggered...

ToxiC inhalaTional injury and ToxiC indusTrial ChemiCals

Apoptosis of SiHa and HCT116 cancer cell-lines by Scorpaenopsis venosa toxic extracts

Spine-venom gland and gonad of the scorpion fish Scorpaenopsis venosa was excised and extracted with Phosphate Buffer Saline. Crude protein was purified using DEAE cellulose anion exchange column chromatography. Protein content of the purified fractions of spine venom gland ranged from 0.053 to 0.076 mg.ml. Whereas, the protein content of the purified gonad extracts ranged from 0.056 to 0.076 m...

Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas.

Cholestatic liver injury appears to result from the induction of hepatocyte apoptosis by toxic bile salts such as glycochenodeoxycholate (GCDC). Previous studies from this laboratory indicate that cathepsin B is a downstream effector protease during the hepatocyte apoptotic process. Because caspases can initiate apoptosis, the present studies were undertaken to determine the role of caspases in...

Toxic epidermal necrolysis: revisiting the tentative link between early apoptosis and late necrosis (review).

Toxic epidermal necrolysis (TEN) is a dramatic drug-induced reaction that may lead to full destruction of the epidermis and epithelial mucosae. The keratinocytes themselves seem to play a major role in the pathogenic mechanism. Biochemical and morphological studies performed on early epidermal lesions demonstrated that keratinocytes undergo apoptosis, but histological and clinical data show evi...